SCHEMBL8060106

SCHEMBL8060106

CC(=O)CNc1c(I)c(NC(C)=O)c(I)c(C(=O)[O-])c1I.[Cs+]

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.71
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5663115 0.84 LMNA (0.57) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL37116 0.84 LMNA (1.00) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL6286191 0.84 LMNA (1.00) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL7198501 0.84 LMNA (0.92) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL19379574 0.82 LMNA (0.96) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL3076099 0.82 LMNA (0.96) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL3338333 0.82 LMNA (0.96) LMNASMN1; SMN2
SCHEMBL8815549 0.80 LMNA (0.92) LMNASMN1; SMN2
Diatrizoic Acid SCHEMBL21243193 0.78 LMNA (0.86) LMNASMN1; SMN2
SCHEMBL8009914 0.75 LMNA (0.45) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0686046-B1 CONTRAST AGENTS NYCOMED IMAGING AS (NO) 2000-05-24 EP disclosed
US-5767299-A Contrast agents NYCOMED IMAGING AS (NO) 1998-06-16 US disclosed
EP-0686046-A1 CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1995-12-13 EP disclosed
WO-1994019025-A2 CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1994-09-01 WO disclosed