Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diatrizoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.31 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diatrizoic Acid SCHEMBL37116 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MEN1KMT2ACA1 | |
| Diatrizoic Acid SCHEMBL3076099 | 0.98 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2A | |
| Diatrizoic Acid SCHEMBL19379574 | 0.98 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2A | |
| Diatrizoic Acid SCHEMBL3338333 | 0.98 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8815549 | 0.96 | LMNA (0.92) | LMNASMN1; SMN2MEN1KMT2ACA1 | |
| Diatrizoic Acid SCHEMBL7198501 | 0.96 | LMNA (0.92) | LMNASMN1; SMN2MEN1KMT2ACA1 | |
| Diatrizoic Acid SCHEMBL21243193 | 0.93 | LMNA (0.86) | LMNASMN1; SMN2MEN1KMT2A | |
| Iothalamic Acid SCHEMBL159919 | 0.86 | LMNA (0.75) | LMNASMN1; SMN2 | |
| Iothalamic Acid SCHEMBL30496108 | 0.86 | LMNA (0.75) | LMNASMN1; SMN2 | |
| Metrizoic Acid SCHEMBL11334827 | 0.84 | LMNA (0.71) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552149-B2 | Polypeptides and use thereof | ALLIGATOR BIOSCIENCE AB (SE) | 2013-10-08 | — | — | US | disclosed |
| US-6884590-B1 | Kit for detecting restriction fragnemt length polymorphism in intracellular adhesion molecules and diagnosing inflammatory bowel disease | CEDARS-SINAI MEDICAL CENTER (US) | 2005-04-26 | — | — | US | disclosed |
| EP-0846266-B1 | DIFFERENTIAL ASSAY FOR ULCERATIVE COLITIS, PRIMARY SCLEROSING CHOLANGITIS AND TYPE 1 AUTOIMMUNE HEPATITIS | CEDARS SINAI MEDICAL CENTER (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-0846266-A4 | DIFFERENTIAL ASSAY FOR ULCERATIVE COLITIS, PRIMARY SCLEROSING CHOLANGITIS AND TYPE 1 AUTOIMMUNE HEPATITIS | CEDARS SINAI MEDICAL CENTER (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0615129-B1 | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis or primary sclerosing cholangitis | CEDARS SINAI MEDICAL CENTER (US) | 2000-05-31 | — | — | EP | disclosed |
| US-6008335-A | A KIT FOR DETECTING FOR INFLAMMATORY BOWEL DISEASE HAVING AN OLIGONUCLEOTIDE PROBE WITH AN ARGININE AT POSITION 241, IMMOBILIZED ON A SOLID MATIX, AND AMPLIFYING THE SUBJECT'S NUCLEIC ACID ENCODING AN INTERCELLULAR ADHESION MOLECULE | CEDARS-SINAI MEDICAL CENTER (US) | 1999-12-28 | — | — | US | disclosed |
| US-5846777-A | Two cDNAs encoding WD-40 proteins | INCYTE PHARMACEUTICALS, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5830675-A | DIFFERENTIATION OF STAINING PATTERN OF PERINUCLEAR ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY FOR DIAGNOSIS OF VARIOUS INFLAMMATORY BOWEL DISEASES | CEDARS-SINAI MEDICAL CENTER (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0846266-A1 | DIFFERENTIAL ASSAY FOR ULCERATIVE COLITIS, PRIMARY SCLEROSING CHOLANGITIS AND TYPE 1 AUTOIMMUNE HEPATITIS | Cedars-Sinai Medical Center (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5750355-A | TESTING FOR THE PRESENCE OR ABSENCE OF A DETECTABLE COMPLEX OF ALCOHOL-FIXED NEUTROPHILS, P-ANCA AND DETECTABLE SECONDARY ANTIBODY, WHEREIN ONLY THE DNA OF THE NEUTROPHILS HAS BEEN DIGESTED BY DNAASE | CEDARS-SINAI MEDICAL CENTER (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0837697-A1 | ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY MATERIAL ASSOCIATED WITH ULCERATIVE COLITIS AND RELATED METHODS AND KITS | Cedars-Sinai Medical Center (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5691151-A | DETECTION OF ANTIBODY | REGENTS OF UNIVERSITY OF CALIFORNIA (US) | 1997-11-25 | — | — | US | disclosed |
| US-5681699-A | ASSAYING NUCLEIC ACID SAMPLE FOR THE PRESENCE OF A CODON ENCODING ARGININE AT AMINO ACID POSITION 241 OF INTERCELLULAR ADHESION MOLECULE-1 | CEDARS-SINAI MEDICAL CENTER (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996041183-A1 | DIFFERENTIAL ASSAY FOR ULCERATIVE COLITIS, PRIMARY SCLEROSING CHOLANGITIS AND TYPE 1 AUTOIMMUNE HEPATITIS | CEDARS-SINAI MEDICAL CENTER (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996039186-A1 | ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY MATERIAL ASSOCIATED WITH ULCERATIVE COLITIS AND RELATED METHODS AND KITS | CEDARS-SINAI MEDICAL CENTER (US) | 1996-12-12 | — | — | WO | disclosed |
| WO-1996012189-A2 | METHODS OF SCREENING FOR ULCERATIVE COLITIS AND CROHN'S DISEASE BY DETECTING VH3-15 AUTOANTIBODY AND pANCA | CEDARS-SINAI MEDICAL CENTER (US) | 1996-04-25 | — | — | WO | disclosed |
| WO-1995021941-A1 | METHODS OF DIAGNOSING ULCERATIVE COLITIS AND CROHN'S DISEASE | CEDARS-SINAI MEDICAL CENTER (US) | 1995-08-17 | — | — | WO | disclosed |
| EP-0615129-A2 | Methods for selectively detecting perinuclear anti-neutrophilcytoplasmic antibody of ulcerative colitis or primary sclerosing cholangitis | Cedars-Sinai Medical Center (US) | 1994-09-14 | — | — | EP | disclosed |