Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Diatrizoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diatrizoic Acid SCHEMBL37116 | 0.96 | LMNA (1.00) | LMNASMN1; SMN2MEN1KMT2ACA1 | |
| Diatrizoic Acid SCHEMBL6286191 | 0.96 | LMNA (1.00) | LMNASMN1; SMN2MEN1KMT2ACA1 | |
| Diatrizoic Acid SCHEMBL3076099 | 0.94 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2A | |
| Diatrizoic Acid SCHEMBL19379574 | 0.94 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2A | |
| Diatrizoic Acid SCHEMBL3338333 | 0.94 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8815549 | 0.92 | LMNA (0.92) | LMNASMN1; SMN2MEN1KMT2ACA1 | |
| Diatrizoic Acid SCHEMBL21243193 | 0.89 | LMNA (0.86) | LMNASMN1; SMN2MEN1KMT2A | |
| Iothalamic Acid SCHEMBL8995665 | 0.86 | LMNA (0.70) | LMNASMN1; SMN2 | |
| SCHEMBL8060106 | 0.84 | LMNA (0.71) | LMNASMN1; SMN2 | |
| Iothalamic Acid SCHEMBL30496108 | 0.83 | LMNA (0.75) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738157-B1 | CONTRAST MEDIA FOR X-RAY AND MAGNETIC RESONANCE IMAGING | AMERSHAM HEALTH AS (NO) | 2003-04-02 | — | — | EP | disclosed |
| EP-0686046-B1 | CONTRAST AGENTS | NYCOMED IMAGING AS (NO) | 2000-05-24 | — | — | EP | disclosed |
| US-5767299-A | Contrast agents | NYCOMED IMAGING AS (NO) | 1998-06-16 | — | — | US | disclosed |
| EP-0738157-A1 | CONTRAST MEDIA FOR X-RAY AND MAGNETIC RESONANCE IMAGING | NYCOMED IMAGING AS (NO) | 1996-10-23 | — | — | EP | disclosed |
| US-5559266-A | Iodinated esters | NYCOMED IMAGING AS (NO) | 1996-09-24 | — | — | US | disclosed |
| WO-1995019186-A2 | CONTRAST MEDIA FOR X-RAY AND MAGNETIC RESONANCE IMAGING | NYCOMED IMAGING A/S (NO) | 1995-07-20 | — | — | WO | disclosed |
| US-5370861-A | Iodinated esters contrast medium and use | NYCOMED IMAGING AS (NO) | 1994-12-06 | — | — | US | disclosed |
| EP-0452377-B1 | IODINATED ESTERS | NYCOMED IMAGING AS (NO) | 1994-09-21 | — | — | EP | disclosed |