Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ESRRB | O95718 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060423 | 1.00 | ALDH1A1 (0.42) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL1691025 | 0.80 | TSHR (0.43) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL206973 | 0.80 | SMN1; SMN2 (0.52) | TDP1SMN1; SMN2CA1CA2KMT2A | |
| SCHEMBL1823637 | 0.80 | TSHR (0.43) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL222024 | 0.80 | SMN1; SMN2 (0.52) | TDP1SMN1; SMN2CA1CA2KMT2A | |
| SCHEMBL205700 | 0.80 | TSHR (0.43) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL9040323 | 0.80 | SMN1; SMN2 (0.52) | TDP1SMN1; SMN2CA1CA2KMT2A | |
| SCHEMBL6061378 | 0.78 | TSHR (0.42) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL7491734 | 0.78 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2CA1CA2KMT2A | |
| Ammonia Solution, Strong SCHEMBL21219123 | 0.78 | SMN1; SMN2 (0.50) | TDP1SMN1; SMN2CA1CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374661-A1 | BIOLOGICALLY ACTIVE MACROLIDES, COMPOSITIONS, AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2015-12-31 | — | — | US | disclosed |
| US-9139595-B2 | Biologically active macrolides, compositions, and uses thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-09-22 | — | — | US | disclosed |
| US-20140243284-A1 | BIOLOGICALLY ACTIVE MACROLIDES, COMPOSITIONS, AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2014-08-28 | — | — | US | disclosed |
| US-8741947-B2 | Biologically active macrolides, compositions, and uses thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2014-06-03 | — | — | US | disclosed |
| EP-0620857-B1 | SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS | GENZYME LTD (GB) | 2000-08-02 | — | — | EP | disclosed |
| US-5686275-A | LACTATE DEHYDROGENASE | GENZYME LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| US-5434289-A | Process for producing optically active β-hydroxyketone | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1995-07-18 | — | — | US | disclosed |
| EP-0620857-A1 | SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS | Genzyme Limited (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993013215-A1 | SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS | GENZYME LIMITED (GB) | 1993-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243284-A1 | BIOLOGICALLY ACTIVE MACROLIDES, COMPOSITIONS, AND USES THEREOF | ABCC9, ABCB11, ATP6V1H | ALDH1A1 3266/4885TDP1 3924/4885MGAM 1239/4885 |
| US-20150374661-A1 | BIOLOGICALLY ACTIVE MACROLIDES, COMPOSITIONS, AND USES THEREOF | ABCC9, ABCB11, ATP6V1H | ALDH1A1 3266/4885TDP1 3924/4885MGAM 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.