Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10361894 | 0.85 | GBA1 (0.40) | GBA1SIGMAR1HTR1AHRH3ACHE | |
| SCHEMBL17274419 | 0.73 | OPRD1 (0.43) | GBA1 | |
| SCHEMBL7394512 | 0.73 | SIGMAR1 (0.35) | GBA1SIGMAR1ACHEBCHE | |
| SCHEMBL9688491 | 0.71 | ACHE (0.60) | KMT2ASIGMAR1HRH3ACHEBCHE | |
| SCHEMBL9653602 | 0.71 | HTR2B (0.42) | GBA1JAK2JAK1SIGMAR1 | |
| SCHEMBL3941806 | 0.69 | ACHE (0.53) | KMT2ASIGMAR1HRH3ACHEBCHE | |
| SCHEMBL3941803 | 0.69 | ACHE (0.53) | KMT2ASIGMAR1HRH3ACHEBCHE | |
| SCHEMBL3943931 | 0.69 | ACHE (0.53) | KMT2ASIGMAR1HRH3ACHEBCHE | |
| SCHEMBL27486053 | 0.68 | GBA1 (0.40) | GBA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3457361 | 0.67 | CHRM2 (0.43) | GBA1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140333-A | FOR TREATMENT AND/OR PROPHYLAXIS OF DISEASES INCLUDE SUCH RESPIRATORY DISEASES AS CHRONIC OBSTRUCTIVE PULMONARY DISEASES, CHRONIC BRONCHITIS, ASTHMA, CHRONIC RESPIRATORY OBSTRUCTION, PULMONARY FIBROSIS, PULMONARY EMPHYSEMA | BANYU PHARMACEUTICAL CO LTD (JP) | 2000-10-31 | — | — | US | disclosed |