Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | PKLR | P30613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060841 | 1.00 | CTSL (0.32) | CTSLALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8058144 | 0.89 | CTSL (0.32) | CTSLALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8058145 | 0.89 | CTSL (0.32) | CTSLALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8056918 | 0.85 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8056913 | 0.85 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8058007 | 0.84 | CTSL (0.35) | CTSLALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL8058006 | 0.84 | CTSL (0.35) | CTSLALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL8056904 | 0.83 | — | — | |
| SCHEMBL8056903 | 0.83 | — | — | |
| SCHEMBL8045172 | 0.82 | VEGFA (0.35) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |