Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060149 | 0.89 | LMNA (0.45) | EPHX2GAAEPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL8066757 | 0.88 | ALDH1A1 (0.43) | EPHX2GAAEPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL8062233 | 0.87 | HTT (0.44) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL4537391 | 0.85 | EPHX1 (0.53) | EPHX2GAAEPHX1ALDH1A1 | |
| SCHEMBL4541299 | 0.83 | EPHX1 (0.51) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL8065000 | 0.81 | EPHX2 (0.42) | EPHX2EPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL8061434 | 0.78 | EPHX2 (0.42) | EPHX2EPHX1 | |
| SCHEMBL4540476 | 0.75 | EPHX2 (0.51) | EPHX2EPHX1L3MBTL1 | |
| SCHEMBL8070984 | 0.75 | KMT2A (0.45) | GAAL3MBTL1 | |
| SCHEMBL4535921 | 0.75 | EPHX1 (0.53) | EPHX2EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |