Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060149 | 0.90 | LMNA (0.45) | ALDH1A1L3MBTL1EPHX1EPHX2GAA | |
| SCHEMBL8061006 | 0.88 | EPHX2 (0.41) | ALDH1A1L3MBTL1EPHX1EPHX2GAA | |
| SCHEMBL8062233 | 0.88 | HTT (0.44) | ALDH1A1EPHX1EPHX2 | |
| SCHEMBL8065000 | 0.85 | EPHX2 (0.42) | ALDH1A1L3MBTL1EPHX1EPHX2HSD11B1 | |
| SCHEMBL4535452 | 0.85 | EPHX2 (0.58) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL4537354 | 0.79 | EPHX1 (0.63) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL8061434 | 0.79 | EPHX2 (0.42) | EPHX1EPHX2 | |
| SCHEMBL8062877 | 0.77 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL8062904 | 0.77 | EPHX2 (0.59) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL4543052 | 0.74 | NPC1 (0.48) | ALDH1A1EPHX1EPHX2AKR1C3AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |