SCHEMBL8062847

SCHEMBL8062847

C=CCC(C(=O)N(C)OC)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 5/20 0.40
FAAH O00519 1/20 0.39
SLC6A2 P23975 2/20 0.38
SLC6A4 P31645 2/20 0.38
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CYP2C19 P33261 1/20 0.36
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
HIF1A Q16665 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8062852 1.00 SLC6A3 (0.40) SLC6A3FAAHSLC6A2SLC6A4ALDH1A1
SCHEMBL8602519 0.88 SLC6A3 (0.41) SLC6A3FAAHSLC6A2SLC6A4ALDH1A1
SCHEMBL624561 0.81 SLC6A3 (0.49) SLC6A3SLC6A2SLC6A4ALDH1A1LMNA
SCHEMBL5879125 0.81 SLC6A3 (0.49) SLC6A3SLC6A2SLC6A4ALDH1A1LMNA
SCHEMBL5879124 0.81 SLC6A3 (0.49) SLC6A3SLC6A2SLC6A4ALDH1A1LMNA
SCHEMBL8067450 0.79 ALDH1A1 (0.43) SLC6A3SLC6A2SLC6A4ALDH1A1LMNA
SCHEMBL8067451 0.79 ALDH1A1 (0.43) SLC6A3SLC6A2SLC6A4ALDH1A1LMNA
SCHEMBL8062703 0.78 SLC6A3 (0.37) SLC6A3SLC6A2SLC6A4ALDH1A1LMNA
SCHEMBL8691676 0.78 TACR2 (0.44) SLC6A3SLC6A2SLC6A4CYP2C19CYP3A4
SCHEMBL9119210 0.78 HPGD (0.44) SLC6A3SLC6A2SLC6A4LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013652-A ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIHISTAMINES MERCK & CO., INC. (US) 2000-01-11 US disclosed
US-5962462-A COMPOUNDS WHICH INHIBIT THE ENTRY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INTO TARGET CELLS; DELAYING THE ONSET OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). MERCK & CO., INC. (US) 1999-10-05 US disclosed
WO-1998025605-A1 SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
US-5739149-A TREATING ASTHMA ZENECA LIMITED (GB) 1998-04-14 US disclosed
US-5635509-A ASTHMA; BRONCHODILATOR AGENTS; VASODILATION MICROVASCULAR PERMEABILITY; MAST CELLS ZENECA LIMITED (GB) 1997-06-03 US disclosed
EP-0702681-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1996-03-27 EP disclosed
EP-0680962-A2 Heterocyclic compounds ZENECA LIMITED (GB) 1995-11-08 EP disclosed
WO-1994029309-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1994-12-22 WO disclosed