Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.45 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059158 | 0.79 | CXCL8 (0.44) | CXCL8CAMK2ATDP1CHRM1AKR1B1 | |
| SCHEMBL8046728 | 0.78 | CXCL8 (0.46) | CXCL8CAMK2ASMN1; SMN2POLBCHRM1 | |
| SCHEMBL8083549 | 0.78 | SRC (0.47) | POLBHPGDTDP1MEN1KMT2A | |
| SCHEMBL8046814 | 0.77 | CXCL8 (0.58) | CXCL8CAMK2ACHRM1MEN1KMT2A | |
| SCHEMBL8061507 | 0.76 | CXCL8 (0.50) | CXCL8CAMK2ACHRM1KMT2ARAB9A | |
| SCHEMBL18607331 | 0.76 | CXCL8 (0.58) | CXCL8CAMK2AHPGDTDP1CHRM1 | |
| SCHEMBL8058401 | 0.75 | CXCL8 (0.46) | CXCL8CAMK2ATDP1CHRM1MEN1 | |
| SCHEMBL8063968 | 0.74 | CXCL8 (0.42) | CXCL8SMN1; SMN2POLBHPGDTDP1 | |
| SCHEMBL8061525 | 0.74 | CXCL8 (0.45) | CXCL8CAMK2AHPGDRAB9AFABP4 | |
| SCHEMBL20472218 | 0.74 | CXCL8 (0.60) | CXCL8CAMK2ATDP1CHRM1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |