Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | LAP3 | P28838 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063993 | 0.78 | CXCL8 (0.45) | HPGDTDP1POLBRAB9AMEN1 | |
| SCHEMBL6978499 | 0.77 | RAB9A (0.43) | HPGDCYP2C19TRPM8TDP1POLB | |
| SCHEMBL3836998 | 0.75 | SRC (0.57) | SRCHPGDCYP2C19TDP1CYP2C9 | |
| SCHEMBL4134981 | 0.75 | CYP2C19 (0.47) | HPGDCYP2C19TRPM8TDP1POLB | |
| SCHEMBL5060516 | 0.74 | CYP2C19 (0.45) | HPGDCYP2C19TRPM8SLC1A3SLC1A2 | |
| SCHEMBL8083709 | 0.72 | CYP19A1 (0.49) | SRCCYP2C19TDP1CYP2C9ANPEP | |
| SCHEMBL25374097 | 0.72 | RAB9A (0.46) | HPGDCYP2C19SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL3245338 | 0.71 | SRC (0.61) | SRCCYP2C19TDP1CYP2C9ANPEP | |
| SCHEMBL28158014 | 0.70 | POLB (0.45) | HPGDCYP2C19TDP1POLBLMNA | |
| SCHEMBL28346201 | 0.70 | SRC (0.50) | SRCCYP2C19TDP1POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044206-A1 | PRODRUGS OF NAALADASE INHIBITORS | Guildford Pharmaceuticals Inc. (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999033849-A1 | PRODRUGS OF NAALADASE INHIBITORS | GUILDFORD PHARMACEUTICALS INC. (US) | 1999-07-08 | — | — | WO | disclosed |