SCHEMBL8064366

SCHEMBL8064366

C=CCc1cc[c]c(/C=N\O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.41
ALDH1A1 P00352 6/20 0.40
MAPT P10636 4/20 0.40
HPGD P15428 4/20 0.40
MEN1 O00255 3/20 0.40
GAA P10253 3/20 0.40
KMT2A Q03164 3/20 0.40
GABRA1 P14867 3/20 0.40
GABRB2 P47870 3/20 0.40
PPARG P37231 2/20 0.40
PPARD Q03181 2/20 0.40
KDM4E B2RXH2 2/20 0.40
CNR1 P21554 2/20 0.40
CNR2 P34972 2/20 0.40
ALDH2 P05091 1/20 0.40
AKR1B1 P15121 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CYP3A4 P08684 3/20 0.35
ALOX5 P09917 2/20 0.35
PTGS1 P23219 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19210373 0.79 TRPA1 (0.34) ALDH1A1MAPTHPGDMEN1GAA
SCHEMBL19210374 0.79 TRPA1 (0.34) ALDH1A1MAPTHPGDMEN1GAA
SCHEMBL27982836 0.79 PNMT (0.33) ALDH1A1CYP3A4SMN1; SMN2
SCHEMBL8059571 0.75 HPGD (0.33) HPGDLMNATSHR
SCHEMBL5888875 0.73 XDH (0.52) XDHALDH1A1MAPTHPGDMEN1
SCHEMBL2161704 0.71 XDH (0.44) XDHALDH1A1MAPTHPGDMEN1
SCHEMBL15067450 0.69 ALDH1A1 (0.32) ALDH1A1MAPTCYP3A4CYP1A2LMNA
SCHEMBL15066916 0.69 HPGD (0.37) ALDH1A1MAPTHPGDMEN1GAA
SCHEMBL15067449 0.69 ALDH1A1 (0.32) ALDH1A1MAPTCYP3A4CYP1A2LMNA
SCHEMBL15067098 0.69 HPGD (0.35) ALDH1A1MAPTHPGDKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015412-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AG (DE) 2000-07-05 EP disclosed
EP-1015420-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AG (DE) 2000-07-05 EP disclosed
WO-1999012892-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed
WO-1999012885-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed