Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28493925 | 1.00 | — | — | |
| Maleic Acid SCHEMBL29022523 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL8157540 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL8157542 | 0.95 | TSHR (0.82) | — | |
| Maleic Acid SCHEMBL2046430 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL2046433 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL6875 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL615 | 0.95 | — | — | |
| Maleic Acid SCHEMBL613 | 0.95 | — | — | |
| Maleic Acid SCHEMBL20487516 | 0.95 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100339-A | COMPRISING A POLYMER WHICH CONTAINS A CYCLIC MONOMER UNIT AND WHICH CONTAINS A REACTIVE GROUP, AND A RESIN COMPOSITION COMPRISING THE SAME; DURABILITY, CHEMICAL RESISTANCE | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2000-08-08 | — | — | US | disclosed |