Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806955 | 0.92 | MMP13 (0.56) | MMP13MMP3KDM4EHSD17B10MAPK14 | |
| SCHEMBL8066650 | 0.90 | MMP13 (0.55) | MMP13MMP3KDM4EHSD17B10MAPK14 | |
| SCHEMBL8067324 | 0.89 | MMP13 (0.66) | MMP13MMP3 | |
| SCHEMBL8070663 | 0.88 | MMP13 (0.53) | MMP13ROCK2ROCK1 | |
| SCHEMBL3804313 | 0.88 | MMP13 (0.68) | MMP13MMP3 | |
| SCHEMBL3804314 | 0.88 | MMP13 (0.68) | MMP13MMP3 | |
| SCHEMBL8065402 | 0.87 | MMP13 (0.55) | MMP13MMP3KDM4EHSD17B10ROCK2 | |
| SCHEMBL8070773 | 0.87 | MMP13 (0.54) | MMP13MMP3KDM4EHSD17B10MAPK14 | |
| SCHEMBL8072927 | 0.84 | MMP13 (0.49) | MMP13 | |
| SCHEMBL3747906 | 0.80 | MMP13 (0.76) | MMP13MMP3KDM4EHSD17B10ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |