Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065171 | 0.88 | SYK (0.35) | KMT2AMEN1CYP1A2KLK7KLK5 | |
| SCHEMBL8079819 | 0.85 | KMT2A (0.39) | KMT2AMEN1CYP1A2KLK5REN | |
| SCHEMBL8073492 | 0.83 | KMT2A (0.38) | KMT2AMEN1CYP1A2KLK5REN | |
| Hydrochloric Acid SCHEMBL8078863 | 0.83 | MEN1 (0.41) | KMT2AMEN1CYP1A2 | |
| SCHEMBL5891464 | 0.83 | MEN1 (0.37) | KMT2AMEN1CYP1A2 | |
| SCHEMBL8065804 | 0.81 | PPARA (0.47) | KMT2APPARAKLK5ATM | |
| SCHEMBL8065509 | 0.78 | KMT2A (0.33) | KMT2AMEN1CYP1A2RENATM | |
| SCHEMBL5891488 | 0.78 | SCN9A (0.43) | KMT2ARENATMSCN9A | |
| SCHEMBL8065165 | 0.77 | KMT2A (0.32) | KMT2AMEN1CYP1A2RENATM | |
| SCHEMBL8961031 | 0.73 | CTSS (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| US-5686472-A | ANTICARCINOGENIC AND -TUMOR AGENTS; SIDE EFFECT REDUCTION; INHIBITION OF FARNESYLATION OF THE RAS PROTEIN | MERCK & CO., INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |