Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 13/20 | 0.75 |
| ▸ | TRPC6 | Q9Y210 | 13/20 | 0.75 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.52 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10087861 | 0.86 | TRPC3 (1.00) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL806653 | 0.84 | TRPC3 (0.54) | TRPC3TRPC6NPC1RAB9ANPSR1 | |
| SCHEMBL23771825 | 0.82 | TRPC3 (1.00) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL806708 | 0.79 | TRPC3 (0.68) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL26458712 | 0.77 | TRPC3 (0.80) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL806600 | 0.76 | TRPC3 (1.00) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL807011 | 0.72 | TRPC3 (0.58) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL798400 | 0.71 | TRPC3 (0.65) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL806710 | 0.71 | TRPC3 (0.65) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL790364 | 0.70 | TRPC3 (0.77) | TRPC3TRPC6TRPA1CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |