Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 12/20 | 0.58 |
| ▸ | TRPC6 | Q9Y210 | 12/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23771823 | 0.74 | TRPC3 (1.00) | TRPC3TRPC6DHODHNPC1SMN1; SMN2 | |
| SCHEMBL806599 | 0.73 | TRPC3 (0.58) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL806654 | 0.72 | TRPC3 (0.75) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL10087862 | 0.72 | TRPC3 (0.60) | TRPC3TRPC6KDM4ENPC1RAB9A | |
| SCHEMBL807014 | 0.71 | TRPC3 (0.73) | TRPC3TRPC6DHODHNPC1RAB9A | |
| SCHEMBL807009 | 0.70 | TRPC3 (0.69) | TRPC3TRPC6DHODHLMNANPC1 | |
| SCHEMBL806600 | 0.68 | TRPC3 (1.00) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL789220 | 0.67 | MAPT (0.53) | TRPC3TRPC6DHODHKDM4ELMNA | |
| SCHEMBL806653 | 0.66 | TRPC3 (0.54) | TRPC3TRPC6NPC1RAB9ANPSR1 | |
| SCHEMBL23771825 | 0.65 | TRPC3 (1.00) | TRPC3TRPC6TRPA1CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |