Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 5/20 | 0.43 |
| ▸ | FNTB | P49356 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064712 | 0.85 | PDE4B (0.45) | CYP11B1CYP11B2FNTAFNTBPDE4B | |
| SCHEMBL3809970 | 0.84 | FNTA (0.50) | CYP11B1CYP11B2GRM2FNTAFNTB | |
| SCHEMBL8053627 | 0.80 | PDE4D (0.42) | PDE4BPDE4DMAPK10 | |
| SCHEMBL8053509 | 0.79 | GRM2 (0.46) | GRM2PDE4BPDE4D | |
| SCHEMBL7913026 | 0.77 | PDE4B (0.43) | PDE4BPDE4D | |
| SCHEMBL7904659 | 0.77 | CYP19A1 (0.47) | PDE4B | |
| SCHEMBL8066491 | 0.75 | PDE4D (0.41) | FNTAFNTBPDE4BPGGT1BPDE4D | |
| SCHEMBL8054760 | 0.75 | HDAC7 (0.55) | PDE4B | |
| SCHEMBL8067827 | 0.74 | GAA (0.51) | PDE4BPDE4D | |
| SCHEMBL8072182 | 0.74 | PDE4D (0.42) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |