Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066070 | 0.89 | HTT (0.57) | HDAC7KMT2ATSHRLMNAKDM4E | |
| SCHEMBL15906189 | 0.86 | KMT2A (0.55) | HDAC7MEN1KMT2ATSHRLMNA | |
| SCHEMBL8065440 | 0.84 | RXFP1 (0.57) | HDAC7MEN1KMT2APOLBRXFP1 | |
| SCHEMBL3806916 | 0.82 | MEN1 (0.50) | HDAC7MEN1KMT2ATSHRLMNA | |
| SCHEMBL8068535 | 0.81 | HDAC7 (0.49) | HDAC7MEN1KMT2APDE4BHTT | |
| SCHEMBL8071515 | 0.79 | HDAC7 (0.45) | HDAC7KMT2APDE4BHTTHDAC2 | |
| SCHEMBL8066228 | 0.78 | HTT (0.48) | TSHRCYP1A2CYP3A4HPGDHTT | |
| SCHEMBL8053373 | 0.76 | POLB (0.46) | MEN1KMT2ACYP2C19PDE4BPOLB | |
| SCHEMBL8064800 | 0.76 | HTT (0.52) | MEN1KMT2ATSHRGAAPDE4B | |
| SCHEMBL8064712 | 0.75 | PDE4B (0.45) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |