Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | FNTA | P49354 | 5/20 | 0.43 |
| ▸ | FNTB | P49356 | 5/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066564 | 0.85 | CYP11B1 (0.49) | PDE4BFNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL3795724 | 0.81 | FNTA (0.50) | PDE4BFNTAFNTBPGGT1BPDE4D | |
| SCHEMBL7904659 | 0.79 | CYP19A1 (0.47) | PDE4B | |
| SCHEMBL8069986 | 0.79 | PDE4B (0.42) | PDE4BFNTAFNTBCTSAPDE4D | |
| SCHEMBL7913026 | 0.77 | PDE4B (0.43) | PDE4BPDE4D | |
| SCHEMBL8064800 | 0.76 | HTT (0.52) | PDE4BPDE4D | |
| SCHEMBL8054760 | 0.75 | HDAC7 (0.55) | PDE4B | |
| SCHEMBL8014205 | 0.75 | PDE4B (0.46) | PDE4BCTSAPDE4D | |
| SCHEMBL8067030 | 0.75 | PDE4D (0.49) | PDE4BPDE4D | |
| SCHEMBL8066867 | 0.75 | PDE4B (0.46) | PDE4BCTSAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |