Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3341164 | 0.90 | REN (0.39) | GPR139TRPM8ADRB3ADRB1ADRB2 | |
| SCHEMBL3341162 | 0.85 | HTR1A (0.39) | GPR139TRPM8ADRB3ADRB1ADRB2 | |
| SCHEMBL3341708 | 0.82 | ADRB2 (0.41) | GPR139TRPM8ADRB3ADRB1ADRB2 | |
| SCHEMBL3341159 | 0.81 | TRPM8 (0.41) | GPR139TRPM8PPARGSLC6A2SLC6A4 | |
| SCHEMBL1567463 | 0.79 | HTT (0.45) | GPR139ADRB3ADRB1ADRB2ALDH1A1 | |
| SCHEMBL1567460 | 0.79 | HTT (0.45) | GPR139ADRB3ADRB1ADRB2ALDH1A1 | |
| SCHEMBL12581027 | 0.78 | ADRB3 (0.44) | GPR139ADRB3ADRB1ADRB2MAPT | |
| SCHEMBL12581020 | 0.78 | ADRB3 (0.44) | GPR139ADRB3ADRB1ADRB2MAPT | |
| SCHEMBL2027362 | 0.78 | HTT (0.43) | GPR139ADRB3ADRB1ADRB2MAPT | |
| SCHEMBL3346867 | 0.77 | TRPM8 (0.42) | GPR139TRPM8ADRB3ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156817-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |