Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 5/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953447 | 0.88 | SHMT2 (0.49) | SHMT2ALPLPIK3C3PIK3CDPIK3R1 | |
| SCHEMBL806765 | 0.87 | LMNA (0.53) | SMN1; SMN2SHMT2ALPLKMT2AMEN1 | |
| SCHEMBL9953524 | 0.86 | SHMT2 (0.54) | SMN1; SMN2SHMT2ALPLPIK3C3PIK3CD | |
| SCHEMBL9954777 | 0.86 | PIK3CD (0.56) | SHMT2ALPLPIK3CDPIK3R1PIK3CA | |
| SCHEMBL16926620 | 0.85 | PIK3C3 (0.61) | SHMT2ALPLPIK3C3KMT2ALMNA | |
| SCHEMBL16996888 | 0.81 | PIK3C3 (0.60) | PIK3C3PIK3R1PIK3CAPIK3CGKMT2A | |
| SCHEMBL30902109 | 0.81 | PI4KA (0.53) | PIK3C3PIK3R1PIK3CAPIK3CGLMNA | |
| SCHEMBL9953017 | 0.81 | PI4KA (0.53) | PIK3C3PIK3R1PIK3CAPIK3CGLMNA | |
| SCHEMBL806771 | 0.80 | SHMT2 (0.55) | SMN1; SMN2SHMT2ALPLKMT2AMEN1 | |
| SCHEMBL806788 | 0.80 | POLB (0.53) | SMN1; SMN2SHMT2ALPLPIK3C3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |