Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092331 | 1.00 | JUN (0.51) | JUNNFKB1CYP17A1CYP19A1KMT2A | |
| SCHEMBL6091145 | 0.84 | GABBR2 (0.53) | KMT2AALDH1A1MEN1LMNAHTT | |
| SCHEMBL12040547 | 0.84 | GABBR2 (0.53) | KMT2AALDH1A1MEN1LMNAHTT | |
| SCHEMBL622342 | 0.84 | CYP17A1 (0.50) | CYP17A1CYP19A1KMT2AALDH1A1MEN1 | |
| SCHEMBL1769996 | 0.82 | MAPT (0.56) | JUNNFKB1CYP17A1CYP19A1KMT2A | |
| SCHEMBL8077622 | 0.82 | MAPT (0.56) | JUNNFKB1CYP17A1CYP19A1KMT2A | |
| SCHEMBL6092094 | 0.81 | HSD11B1 (0.51) | KMT2AALDH1A1MEN1HSD11B1LMNA | |
| SCHEMBL18317450 | 0.81 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1LMNAHTT | |
| SCHEMBL18325433 | 0.81 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1LMNAHTT | |
| SCHEMBL6090902 | 0.81 | CYP1A2 (0.51) | KMT2AALDH1A1MEN1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640072-B1 | Derivatives of pyridine as hydroxylase and lyase inhibitors | BTG INT LTD (GB) | 2000-08-23 | — | — | EP | disclosed |
| US-5595995-A | ANTICARCINOGENIC AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-01-21 | — | — | US | disclosed |
| EP-0640072-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BTG INTERNATIONAL LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023375-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |