Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546750 | 0.80 | BRD4 (0.50) | BRD4ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL8059219 | 0.80 | KDM4E (0.44) | BRD4AURKAMAPK10RIPK1KDM4E | |
| SCHEMBL7554186 | 0.79 | MCL1 (0.46) | KDM4EALDH1A1HPGD | |
| SCHEMBL8068409 | 0.79 | ALDH1A1 (0.48) | BRD4AURKAMAPK10RIPK1KDM4E | |
| SCHEMBL8074787 | 0.77 | MTNR1A (0.45) | BRD4AURKAMAPK10RIPK1KDM4E | |
| SCHEMBL27408415 | 0.75 | ALDH1A1 (0.54) | KDM4EHTR6ALDH1A1HSD17B10TUBB4A | |
| SCHEMBL7276418 | 0.74 | TSHR (0.56) | MAPK10KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL15623065 | 0.73 | MCL1 (0.75) | HTR6ALDH1A1MAPTHTR1ADRD2 | |
| SCHEMBL8959749 | 0.72 | KDM4E (0.51) | KDM4EHTR6ALDH1A1HSD17B10TUBB4A | |
| SCHEMBL22548162 | 0.71 | BRD4 (0.70) | BRD4ALDH1A1MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803501-B1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMA (JP) | 2000-07-05 | — | — | EP | disclosed |
| EP-0803501-A1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-29 | — | — | EP | disclosed |