Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15018685 | 1.00 | KDM1A (0.50) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL31349197 | 1.00 | KDM1A (0.50) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL13779890 | 1.00 | KDM1A (0.50) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL30968147 | 1.00 | KDM1A (0.50) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL3202238 | 1.00 | KDM1A (0.50) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL3196912 | 1.00 | KDM1A (0.50) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| Hydrochloric Acid SCHEMBL2590934 | 0.98 | KDM1A (0.53) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL3228205 | 0.77 | KDM1A (0.47) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL1239150 | 0.77 | KDM1A (0.47) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D | |
| SCHEMBL10557020 | 0.77 | KDM1A (0.47) | KDM1AHTR2ASIGMAR1ANPEPGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993002707-A1 | NEW ANTI-DIARRHEIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-02-18 | — | — | WO | claimed |
| US-9403763-B2 | CD4-mimetic inhibitors of HIV-1 entry and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-02 | — | — | US | disclosed |
| US-20140350113-A1 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-11-27 | — | — | US | disclosed |
| WO-2013090696-A1 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
| US-20100029985-A1 | Process | AVECIA PHARMACEUTICALS LIMITED (GB) | 2010-02-04 | — | — | US | disclosed |
| US-20100029985-A1 | Process | AVECIA PHARMACEUTICALS LIMITED (GB) | 2010-02-04 | — | — | US | disclosed |
| WO-2009037416-A1 | PROCESS FOR PREPARING SULPHONAMIDES | NPIL PHARMACEUTICALS (UK) LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009037497-A1 | PROCESS FOR PREPARING SULPHONAMIDES | NPIL PHARMACEUTICALS (UK) LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |
| WO-2004082687-A1 | LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-09-30 | — | — | WO | disclosed |
| EP-0659076-A1 | 7-((SUBSTITUTED)AMINO)-8-(((SUBSTITUTED)CARBONYL)-METHYLAMINO)-1-OXASPIRO(4,5)DECANES USEFUL IN PARKINSON'S DISEASE, DYSTONIA, AND OTHER MOVEMENT DISORDERS | WARNER-LAMBERT COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |
| US-5369105-A | Administering to humans | WARNER-LAMBERT COMPANY (US) | 1994-11-29 | — | — | US | disclosed |
| US-5317028-A | 7-((substituted)amino)-8((substituted)carbonyl)-methylamino-1-oxaspiro(4,5)decanes useful in Parkinson's disease, dystonia, and other movement disorders | WARNER-LAMBERT CO. (US) | 1994-05-31 | — | — | US | disclosed |
| WO-1994005284-A1 | 7-((SUBSTITUTED)AMINO)-8-(((SUBSTITUTED)CARBONYL)-METHYLAMINO)-1-OXASPIRO(4,5)DECANES USEFUL IN PARKINSON'S DISEASE, DYSTONIA, AND OTHER MOVEMENT DISORDERS | WARNER-LAMBERT COMPANY (US) | 1994-03-17 | — | — | WO | disclosed |
| WO-1993002707-A1 | NEW ANTI-DIARRHEIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-02-18 | — | — | WO | disclosed |
| US-5063242-A | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino-1-oxaspiro[4,5]decanes as diuretics antiinflammatory, and cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0393696-A2 | 7-(Substituted)amino)-8-(substituted)Carbonyl)-methylamino-1-oxaspiro (4,5)decanes as diuretics antiinflammatory, and cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1990-10-24 | — | — | EP | disclosed |
| US-4965278-A | 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029985-A1 | Process | ADH1A, ADH1C, AKR1C3 | KDM1A 1206/4885HTR2A 1435/4885SIGMAR1 483/4885 |
| US-20140350113-A1 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF | CD4, CD14, CCR5 | KDM1A 4369/4885HTR2A 1496/4885SIGMAR1 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.