Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070457 | 0.86 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2IDO1TDO2LMNA | |
| SCHEMBL8073660 | 0.81 | KDM4E (0.44) | ALDH1A1SMN1; SMN2IDO1TDO2LMNA | |
| SCHEMBL8070339 | 0.81 | RPS6KB2 (0.57) | ALDH1A1SMN1; SMN2IDO1TDO2LMNA | |
| SCHEMBL5259174 | 0.75 | PDE5A (0.44) | SMN1; SMN2LMNAMAPTTP53MEN1 | |
| SCHEMBL7304349 | 0.74 | RAB9A (0.47) | ALDH1A1SMN1; SMN2IDO1TDO2LMNA | |
| SCHEMBL11213463 | 0.73 | PDE5A (0.49) | KDM4EMAPTGAAPKMTUBB4A | |
| SCHEMBL8073867 | 0.73 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2IDO1TDO2LMNA | |
| SCHEMBL8068649 | 0.73 | HSD17B10 (0.69) | ALDH1A1SMN1; SMN2IDO1TDO2LMNA | |
| SCHEMBL8059785 | 0.72 | KDM4E (0.55) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL8070560 | 0.72 | KDM4E (0.52) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150372-A | IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES; BLOCKING INTRACELLULAR SIGNAL TRANSDUCTION AND ACTIVATION OF TRANSCRIPTION FACTORS; KINASE INHIBITORS; ANTIARTHRITIC, ISCHEMIC AGENTS, MULTIPLE SCLEROSIS, TRANSPLANT REJECTION | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-5939421-A | TREATMENT OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, TRANSPLANT REJECTION; INHIBIT KINASE(S) THAT REGULATE ACTIVATION OF TRANSCRIPTION FACTORS TO PREVENT PRODUCTION OF INFLAMMATORY PROTEINS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1999001441-A1 | QUINAZOLINE ANALOGS AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |