Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8059609 | 0.99 | SMN1; SMN2 (0.40) | SMN1; SMN2HPGDTSHRHTTF10 | |
| SCHEMBL8379266 | 0.94 | HPGD (0.41) | SMN1; SMN2HPGDTSHRHTTF10 | |
| SCHEMBL8743801 | 0.94 | PARP10 (0.40) | SMN1; SMN2HPGDTSHRHTTF10 | |
| Hydrochloric Acid SCHEMBL8374986 | 0.93 | HPGD (0.40) | SMN1; SMN2HPGDTSHRHTTF10 | |
| Hydrochloric Acid SCHEMBL8743791 | 0.93 | PARP10 (0.40) | F10PLAUMRGPRX1 | |
| SCHEMBL8743804 | 0.93 | KMT2A (0.41) | SMN1; SMN2HTTF10 | |
| SCHEMBL8743793 | 0.93 | MRGPRX1 (0.44) | SMN1; SMN2HPGDF10MRGPRX1LMNA | |
| SCHEMBL8499411 | 0.93 | GCK (0.42) | F10PLAUGCK | |
| SCHEMBL8446348 | 0.92 | CA2 (0.43) | TSHRHTTF10MRGPRX1KDM4E | |
| Hydrochloric Acid SCHEMBL8743783 | 0.92 | MRGPRX1 (0.44) | SMN1; SMN2HPGDF10MRGPRX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |