Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8374986 | 0.99 | HPGD (0.40) | HPGDMAPTRAB9ASTSICAM1 | |
| SCHEMBL8068683 | 0.94 | SMN1; SMN2 (0.41) | HPGDMAPTSMN1; SMN2KDM4EMRGPRX1 | |
| Hydrochloric Acid SCHEMBL8059609 | 0.93 | SMN1; SMN2 (0.40) | HPGDMAPTSMN1; SMN2KDM4EMRGPRX1 | |
| SCHEMBL8743801 | 0.91 | PARP10 (0.40) | HPGDSMN1; SMN2MRGPRX1PLAUF10 | |
| Hydrochloric Acid SCHEMBL8743791 | 0.90 | PARP10 (0.40) | MRGPRX1PLAUF10 | |
| SCHEMBL8743793 | 0.90 | MRGPRX1 (0.44) | HPGDSMN1; SMN2MRGPRX1CA12CA1 | |
| SCHEMBL8743804 | 0.90 | KMT2A (0.41) | SMN1; SMN2F10ALDH1A1KMT2AHTT | |
| SCHEMBL8499411 | 0.89 | GCK (0.42) | PLAUF10GCK | |
| SCHEMBL8446348 | 0.89 | CA2 (0.43) | MAPTKDM4EMRGPRX1CA1CA2 | |
| Hydrochloric Acid SCHEMBL8743787 | 0.89 | KMT2A (0.41) | HPGDMAPTSMN1; SMN2KDM4EF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880156-A | ANTIARRHYTHMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |
| EP-0627413-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AG (DE) | 1997-09-24 | — | — | EP | disclosed |
| EP-0627413-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-07 | — | — | EP | disclosed |