Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.43 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103400 | 0.95 | RAB9A (0.45) | THRBRAB9ANPC1CYP1A2HSD17B10 | |
| SCHEMBL8069504 | 0.91 | STIM1 (0.46) | STIM1ORAI1ORAI2RAB9ANPC1 | |
| SCHEMBL3104227 | 0.86 | RAB9A (0.44) | STIM1ORAI1ORAI2RAB9ANPC1 | |
| SCHEMBL647154 | 0.84 | RAB9A (0.43) | RAB9ANPC1CYP1A2MAPTMEN1 | |
| SCHEMBL8236747 | 0.82 | NPC1 (0.46) | THRBRAB9ANPC1HSD17B10LMNA | |
| SCHEMBL8234041 | 0.82 | NPC1 (0.39) | THRBRAB9ANPC1HSD17B10MAPT | |
| SCHEMBL8055351 | 0.81 | IL2 (0.42) | STIM1ORAI1ORAI2IL2ABL1 | |
| SCHEMBL8234426 | 0.81 | RAB9A (0.45) | THRBRAB9ANPC1HSD17B10LMNA | |
| SCHEMBL8236417 | 0.81 | RAB9A (0.51) | THRBRAB9ANPC1HSD17B10LMNA | |
| SCHEMBL8234051 | 0.81 | ALOX15 (0.49) | THRBCYP1A2HSD17B10MAPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038775-A1 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-03-26 | — | — | WO | disclosed |