Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | IL2 | P60568 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104227 | 0.95 | RAB9A (0.44) | STIM1ORAI1ORAI2RAB9AGRM5 | |
| SCHEMBL8069094 | 0.91 | STIM1 (0.43) | STIM1ORAI1ORAI2LCKRAB9A | |
| SCHEMBL3103400 | 0.87 | RAB9A (0.45) | RAB9AGRM5NPC1CYP1A2IL2 | |
| SCHEMBL647154 | 0.83 | RAB9A (0.43) | RAB9ANPC1CYP1A2IL2MEN1 | |
| SCHEMBL647823 | 0.77 | RET (0.36) | RAB9AGRM5NPC1CYP1A2MEN1 | |
| SCHEMBL8062134 | 0.77 | STIM1 (0.44) | STIM1ORAI1ORAI2IL2MEN1 | |
| SCHEMBL8070992 | 0.76 | STIM1 (0.44) | STIM1ORAI1ORAI2LCKIL2 | |
| SCHEMBL10151672 | 0.76 | RAB9A (0.44) | RAB9AGRM5NPC1CYP1A2IL2 | |
| SCHEMBL646105 | 0.76 | RAB9A (0.43) | RAB9ANPC1CYP1A2IL2MEN1 | |
| SCHEMBL648258 | 0.76 | STIM1 (0.36) | STIM1ORAI1RAB9AGRM5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038775-A1 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-03-26 | — | — | WO | disclosed |