Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 13/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3097793 | 0.96 | IL2 (0.44) | IL2STIM1ORAI1ORAI2KAT6A | |
| SCHEMBL3109398 | 0.85 | IL2 (0.41) | IL2KAT6A | |
| SCHEMBL8069094 | 0.81 | STIM1 (0.43) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL3105832 | 0.80 | IL2 (0.41) | IL2STIM1ORAI1ORAI2JAK1 | |
| SCHEMBL3103400 | 0.77 | RAB9A (0.45) | IL2 | |
| SCHEMBL8060869 | 0.76 | IL2 (0.41) | IL2 | |
| SCHEMBL3092144 | 0.75 | IL2 (0.46) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL8062134 | 0.74 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL451062 | 0.73 | IL2 (0.62) | IL2CREBBPRAF1BRAFABL1 | |
| SCHEMBL8069504 | 0.73 | STIM1 (0.46) | IL2STIM1ORAI1ORAI2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038775-A1 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-03-26 | — | — | WO | disclosed |