Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | BRD2 | P25440 | 4/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060981 | 0.89 | PSEN1 (0.45) | PAX8 | |
| SCHEMBL8069510 | 0.87 | BRD4 (0.53) | BRD4BRD2BRD3BRDT | |
| SCHEMBL4536836 | 0.81 | BRD4 (0.55) | BRD4BRD2BRD3BRDTRAB9A | |
| SCHEMBL4535339 | 0.80 | ATM (0.47) | RAB9APAX8 | |
| SCHEMBL4542333 | 0.78 | PSEN1 (0.51) | PAX8 | |
| SCHEMBL4541154 | 0.78 | RAB9A (0.56) | RAB9APAX8 | |
| SCHEMBL4538787 | 0.78 | PSEN1 (0.51) | PAX8 | |
| SCHEMBL4541859 | 0.77 | RAB9A (0.54) | RAB9A | |
| SCHEMBL8064995 | 0.77 | BDKRB1 (0.51) | — | |
| SCHEMBL4536842 | 0.77 | RAB9A (0.50) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |