Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.55 |
| ▸ | BRD2 | P25440 | 4/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537510 | 0.89 | RAB9A (0.56) | RAB9APAX8NPC1ALDH1A1NCOA1 | |
| SCHEMBL8069510 | 0.88 | BRD4 (0.53) | BRD4BRD2BRD3BRDTALDH1A1 | |
| SCHEMBL4537477 | 0.87 | NCOA1 (0.53) | RAB9APAX8NPC1NCOA1NCOA3 | |
| SCHEMBL4537550 | 0.87 | PAX8 (0.56) | RAB9APAX8ALDH1A1 | |
| SCHEMBL4536839 | 0.83 | BRD4 (0.56) | BRD4BRD2BRD3BRDTRAB9A | |
| SCHEMBL8069490 | 0.81 | BRD4 (0.51) | BRD4BRD2BRD3BRDTRAB9A | |
| SCHEMBL4542139 | 0.80 | PAX8 (0.45) | RAB9APAX8NPC1HCRTR1HCRTR2 | |
| SCHEMBL4535463 | 0.80 | HTR7 (0.55) | RAB9ANPC1NCOA1NCOA3 | |
| SCHEMBL4535339 | 0.79 | ATM (0.47) | RAB9APAX8 | |
| SCHEMBL4531591 | 0.78 | DRD2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |