SCHEMBL8074044

SCHEMBL8074044

COc1cc(OC)nc(C(=O)NS(=O)(=O)c2ccccc2Cl)n1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 1/20 0.52
FLT4 P35916 1/20 0.52
KDR P35968 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.49
POLB P06746 1/20 0.49
LMNA P02545 2/20 0.46
CCR4 P51679 1/20 0.46
MAPT P10636 1/20 0.46
LGALS8 O00214 1/20 0.45
LGALS3 P17931 1/20 0.45
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 1/20 0.43
GAA P10253 1/20 0.42
GUSB P08236 1/20 0.41
BCAT1 P54687 1/20 0.41
CTSA P10619 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8069688 0.86 CCR4 (0.44) FLT1FLT4KDRSMN1; SMN2CCR4
SCHEMBL7006978 0.84 KMT2A (0.54) SMN1; SMN2POLBMAPTALDH1A1NPC1
SCHEMBL9852812 0.82 NPSR1 (0.47) FLT1FLT4KDRSMN1; SMN2POLB
SCHEMBL7628463 0.82 SMN1; SMN2 (0.44) FLT1FLT4KDRSMN1; SMN2KDM4E
SCHEMBL11265505 0.79 KDM4E (0.55) SMN1; SMN2LMNAKDM4EALDH1A1NPC1
SCHEMBL7012354 0.79 SMN1; SMN2 (0.40) SMN1; SMN2MAPTKDM4EALDH1A1GAA
SCHEMBL11555306 0.78 SMN1; SMN2 (0.65) FLT1FLT4KDRSMN1; SMN2LMNA
SCHEMBL1535824 0.78 SMN1; SMN2 (0.43) SMN1; SMN2LMNAMAPTKDM4EALDH1A1
SCHEMBL7226876 0.77 FLT1 (0.49) FLT1FLT4KDRSMN1; SMN2POLB
SCHEMBL11276176 0.76 ALDH1A1 (0.53) SMN1; SMN2POLBLMNAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0592680-B1 N-sulfonated carboxamide derivatives as fungicides for plants KUMIAI CHEMICAL INDUSTRY CO (JP) 2000-07-19 EP disclosed
US-5536837-A PLANT FUNGICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1996-07-16 US disclosed
US-5478799-A Herbicide for weeds and fungicide for crops KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-12-26 US disclosed
US-5444060-A Applying to control pathogenic fungi KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-08-22 US disclosed
EP-0592680-A1 N-SULFONYLATED, SIX-MEMBERED NITROGENOUS AROMATIC CARBOXAMIDE DERIVATIVE OR SALT THEREOF, PRODUCTION THEREOF, AND PEST CONTROL AGENT KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-04-20 EP disclosed