Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15105591 | 1.00 | HDAC6 (0.37) | HDAC6HDAC1HDAC8FPR2TIPARP | |
| SCHEMBL806729 | 0.86 | FPR2 (0.39) | FPR2TIPARPGPR119SLC6A9 | |
| SCHEMBL15105703 | 0.86 | FPR2 (0.39) | FPR2TIPARPGPR119SLC6A9 | |
| SCHEMBL806717 | 0.81 | GPR119 (0.37) | TIPARPGPR119SLC6A9KCNH2 | |
| SCHEMBL15105719 | 0.81 | GPR119 (0.37) | TIPARPGPR119SLC6A9KCNH2 | |
| SCHEMBL15105501 | 0.81 | TIPARP (0.34) | HDAC6HDAC1HDAC8FPR2TIPARP | |
| SCHEMBL15105502 | 0.81 | TIPARP (0.34) | HDAC6HDAC1HDAC8FPR2TIPARP | |
| SCHEMBL15105498 | 0.80 | TIPARP (0.33) | HDAC6HDAC1HDAC8TIPARPGPR119 | |
| SCHEMBL15105499 | 0.80 | TIPARP (0.33) | HDAC6HDAC1HDAC8TIPARPGPR119 | |
| SCHEMBL15105696 | 0.80 | GPR119 (0.38) | HDAC6HDAC1HDAC8TIPARPGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130184257-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2013-07-18 | — | — | US | claimed |
| US-20130184257-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2013-07-18 | — | — | US | disclosed |
| US-20130184257-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2013-07-18 | — | — | US | disclosed |
| WO-2012037393-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184257-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | GPR119, GPR139, GPR180 | HDAC6 1868/4885HDAC1 1056/4885HDAC8 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.