Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079292 | 0.89 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8069944 | 0.76 | HDAC1 (0.57) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4048387 | 0.73 | MAPT (0.57) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8084008 | 0.73 | HDAC1 (0.76) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8079294 | 0.71 | HDAC6 (0.49) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8311235 | 0.71 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8972594 | 0.71 | HDAC3 (0.59) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL14345841 | 0.70 | HDAC1 (0.74) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8079286 | 0.70 | HDAC3 (0.70) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4324281 | 0.69 | CTSL (0.51) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |