Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069944 | 0.84 | HDAC1 (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8079292 | 0.82 | HDAC1 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8117247 | 0.78 | HDAC6 (0.63) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4048387 | 0.73 | MAPT (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8079286 | 0.73 | HDAC3 (0.70) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8059127 | 0.73 | HDAC3 (0.49) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8059137 | 0.73 | MAPT (0.47) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8075112 | 0.72 | SSTR1 (0.56) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8070047 | 0.71 | HDAC1 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8081630 | 0.71 | HDAC6 (0.47) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |