Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 19/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056592 | 0.90 | MMP13 (0.59) | MMP13EPHX2NR1H4 | |
| SCHEMBL4182437 | 0.87 | MMP13 (0.61) | MMP13EPHX2NR1H4 | |
| SCHEMBL3694242 | 0.87 | MMP13 (0.62) | MMP13 | |
| SCHEMBL8069852 | 0.85 | MMP13 (0.47) | MMP13EPHX2NR1H4 | |
| SCHEMBL8061043 | 0.79 | MMP13 (0.51) | MMP13EPHX2NR1H4 | |
| SCHEMBL3688685 | 0.78 | MMP13 (0.63) | MMP13 | |
| SCHEMBL8066935 | 0.77 | MMP13 (0.87) | MMP13 | |
| SCHEMBL8066880 | 0.77 | XDH (0.56) | MMP13 | |
| SCHEMBL8072180 | 0.77 | MMP13 (0.87) | MMP13 | |
| SCHEMBL8068866 | 0.76 | MMP13 (0.57) | MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101815710-A | Pyrimidine and pyridine derivatives, their pharmaceutical use and compositions | PFIZER | 2010-08-25 | — | — | CN | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |