Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.52 |
| ▸ | MMP13 | P45452 | 5/20 | 0.52 |
| ▸ | MMP3 | P08254 | 12/20 | 0.43 |
| ▸ | MMP2 | P08253 | 10/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5488356 | 0.87 | LTA4H (0.47) | MMP1MMP13MMP3MMP2 | |
| SCHEMBL5488359 | 0.87 | LTA4H (0.47) | MMP1MMP13MMP3MMP2 | |
| SCHEMBL8068667 | 0.85 | MMP1 (0.58) | MMP1MMP13MMP3MMP2MMP9 | |
| SCHEMBL14492870 | 0.82 | MMP1 (0.37) | MMP1MMP13MMP3MMP2 | |
| SCHEMBL14492872 | 0.81 | LTA4H (0.46) | MMP1MMP13 | |
| SCHEMBL5098019 | 0.79 | MMP1 (0.67) | MMP1MMP13MMP3MMP2MMP9 | |
| SCHEMBL9714246 | 0.79 | MMP1 (0.67) | MMP1MMP13MMP3MMP2MMP9 | |
| SCHEMBL5488362 | 0.77 | MMP1 (0.49) | MMP1MMP13MMP3MMP2 | |
| SCHEMBL5488364 | 0.77 | MMP1 (0.49) | MMP1MMP13MMP3MMP2 | |
| SCHEMBL6945106 | 0.76 | CTSS (0.40) | MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066662-A | USE IN CONTROL OR PREVENTION OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS OR IN THE TREATMENT OF INVASIVE TUMOURS, ATHEROSCLEROSIS OR MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. (US) | 2000-05-23 | — | — | US | disclosed |