Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.58 |
| ▸ | MMP13 | P45452 | 5/20 | 0.58 |
| ▸ | MMP2 | P08253 | 11/20 | 0.57 |
| ▸ | MMP3 | P08254 | 10/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070574 | 0.85 | MMP1 (0.52) | MMP1MMP13MMP2MMP3MMP7 | |
| SCHEMBL4633112 | 0.76 | MMP3 (0.74) | MMP1MMP13MMP2MMP3MMP7 | |
| SCHEMBL5088865 | 0.76 | MMP3 (0.74) | MMP1MMP13MMP2MMP3MMP7 | |
| SCHEMBL8483002 | 0.74 | MMP3 (0.57) | MMP1MMP13MMP2MMP3MMP7 | |
| SCHEMBL5488356 | 0.73 | LTA4H (0.47) | MMP1MMP13MMP2MMP3 | |
| SCHEMBL5488359 | 0.73 | LTA4H (0.47) | MMP1MMP13MMP2MMP3 | |
| SCHEMBL8054978 | 0.73 | MMP3 (1.00) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8042125 | 0.73 | MMP3 (1.00) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8060175 | 0.73 | MMP3 (1.00) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL7452415 | 0.73 | MMP1 (1.00) | MMP1MMP13MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066662-A | USE IN CONTROL OR PREVENTION OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS OR IN THE TREATMENT OF INVASIVE TUMOURS, ATHEROSCLEROSIS OR MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. (US) | 2000-05-23 | — | — | US | disclosed |