Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139715 | 1.00 | SRC (0.47) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL571797 | 0.85 | LMNA (0.48) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL162139 | 0.85 | LMNA (0.48) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL14691171 | 0.85 | LMNA (0.48) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL190036 | 0.85 | LMNA (0.48) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL31477299 | 0.84 | KMT2A (0.53) | LMNAMTNR1AMTNR1BHPGDALDH1A1 | |
| SCHEMBL24015849 | 0.83 | MTNR1A (0.49) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL30819117 | 0.83 | MTNR1A (0.49) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL24015864 | 0.83 | MTNR1A (0.49) | SRCLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL19658444 | 0.83 | AOC3 (0.55) | SRCLMNAMTNR1AMTNR1BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025516-A | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes | CHIRAGENE, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1998027051-A9 | CATALYTIC ASYMMETRIC AMIDOHYDROXYLATION OF OLEFINS WITH N-HALO CARBOXAMIDES | — | 1998-11-12 | — | — | WO | disclosed |
| WO-1998027051-A2 | CATALYTIC ASYMMETRIC AMIDOHYDROXYLATION OF OLEFINS WITH N-HALO CARBOXAMIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-06-25 | — | — | WO | disclosed |
| CN-1102829-A | Synthesis of taxol, taxol analogs and intermediates thereof and compositions thereof | BRYN MAWR COLLEGE (US) | 1995-05-24 | — | — | CN | disclosed |