SCHEMBL8070733

SCHEMBL8070733

CN1C2C=CC(C2)C1c1cccnc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.46
CHRNA7 P36544 3/20 0.46
CHRNA4 P43681 3/20 0.46
ALDH1A1 P00352 2/20 0.43
CHRNB4 P30926 2/20 0.43
CHRNA3 P32297 2/20 0.43
CHRNA2 Q15822 2/20 0.43
LMNA P02545 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
HTR3E A5X5Y0 1/20 0.43
PSIP1 O75475 1/20 0.43
TRPA1 O75762 1/20 0.43
HTR3B O95264 1/20 0.43
CHRNA1 P02708 1/20 0.43
CHRNG P07510 1/20 0.43
MAPT P10636 1/20 0.43
CHRNB1 P11230 1/20 0.43
CYP2A6 P11509 1/20 0.43
PTGS1 P23219 1/20 0.43
CHRNA5 P30532 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30116774 0.87 CHRNA7 (0.46) CHRNB2CHRNA7CHRNA4ALDH1A1CHRNB4
SCHEMBL8076992 0.87 CHRNA7 (0.46) CHRNB2CHRNA7CHRNA4ALDH1A1CHRNB4
SCHEMBL8077458 0.81 CYP2A6 (0.40) ALDH1A1CYP2A6
SCHEMBL9058332 0.81 CYP2A6 (0.40) ALDH1A1CYP2A6
SCHEMBL8062972 0.79 CHRNB2 (0.35) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1
Fumaric Acid SCHEMBL9085199 0.77 KDM4E (0.43) CHRNA7ALDH1A1LMNATDP1
SCHEMBL8075941 0.75 TP53 (0.51) ALDH1A1MAPT
SCHEMBL8072336 0.75 ALDH1A1 (0.43) ALDH1A1LMNATDP1MAPT
SCHEMBL8072071 0.75 CHRNB2 (0.38) CHRNB2CHRNA4
SCHEMBL8072339 0.73 DRD4 (0.44) ALDH1A1TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6100269-A ADMINISTERING TO PATIENT NICOTINIC RECEPTOR AGONISTIC DERIVATIVES OF 3-(PYRIDYL OR PYRIMIDYL)-2-AZABICYCLO(2.2.1) HEPTANE OR 2-AZABICYCLO(2.2.2.)OCTANE TO ELICIT NEUROTRANSMITTER SECRETION WITH REDUCED SIDE EFFECTS BENCHERIF MEROUANE (US) 2000-08-08 US disclosed
US-5583140-A ADMINISTERING 2-AZABICYCLO(2.2.2)OCT-5-ENE DERIVATIVES TO TREAT NEURODEGENERATIVE DISORDERS SUCH AS SENILE DEMENTIA OF ALZHEIMER'S TYPE TARGACEPT, INC. A CORP. OF DE, 1996-12-10 US disclosed
WO-1996036637-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-11-21 WO disclosed
WO-1996036637-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-11-21 WO disclosed