Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072339 | 0.81 | DRD4 (0.44) | ALDH1A1KDM4EMAPTGAACNR1 | |
| SCHEMBL8070733 | 0.75 | CHRNB2 (0.46) | ALDH1A1MAPTLMNATDP1 | |
| SCHEMBL9058332 | 0.72 | CYP2A6 (0.40) | ALDH1A1KDM4ENPSR1 | |
| SCHEMBL8077458 | 0.72 | CYP2A6 (0.40) | ALDH1A1KDM4ENPSR1 | |
| SCHEMBL8075941 | 0.67 | TP53 (0.51) | ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL30116774 | 0.66 | CHRNA7 (0.46) | ALDH1A1KDM4EMAPTLMNANPSR1 | |
| SCHEMBL8076992 | 0.66 | CHRNA7 (0.46) | ALDH1A1KDM4EMAPTLMNANPSR1 | |
| SCHEMBL11057486 | 0.64 | GFER (0.76) | ALDH1A1 | |
| SCHEMBL18647515 | 0.62 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTGAAL3MBTL1 | |
| SCHEMBL24154837 | 0.62 | KDM4E (0.42) | ALDH1A1KDM4EMAPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100269-A | ADMINISTERING TO PATIENT NICOTINIC RECEPTOR AGONISTIC DERIVATIVES OF 3-(PYRIDYL OR PYRIMIDYL)-2-AZABICYCLO(2.2.1) HEPTANE OR 2-AZABICYCLO(2.2.2.)OCTANE TO ELICIT NEUROTRANSMITTER SECRETION WITH REDUCED SIDE EFFECTS | BENCHERIF MEROUANE (US) | 2000-08-08 | — | — | US | disclosed |
| US-5583140-A | ADMINISTERING 2-AZABICYCLO(2.2.2)OCT-5-ENE DERIVATIVES TO TREAT NEURODEGENERATIVE DISORDERS SUCH AS SENILE DEMENTIA OF ALZHEIMER'S TYPE | TARGACEPT, INC. A CORP. OF DE, | 1996-12-10 | — | — | US | disclosed |
| WO-1996036637-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | R.J. REYNOLDS TOBACCO COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| WO-1996036637-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | R.J. REYNOLDS TOBACCO COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |