Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28856434 | 0.78 | NR1H2 (0.39) | ALOX15HSD17B10LIPGCYP2D6CYP2C19 | |
| SCHEMBL5823386 | 0.75 | PNMT (0.58) | LIPGDRD2CYP2D6CYP2C19DRD4 | |
| SCHEMBL28825898 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A | |
| SCHEMBL29911116 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A | |
| SCHEMBL6675428 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A | |
| SCHEMBL574897 | 0.74 | LIPG (0.42) | LIPGHTR2AHTR2BKCNH2ALOX5 | |
| SCHEMBL407782 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A | |
| SCHEMBL6672769 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A | |
| SCHEMBL1449245 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A | |
| SCHEMBL28103115 | 0.74 | PNMT (0.57) | LIPGDRD2CYP2D6CYP2C19HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032394-A1 | USE OF SUBSTITUTED 11-PHENYL-DIBENZAZEPINE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION, DIARRHEA AND SCOUR | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999026628-A1 | USE OF SUBSTITUTED 11-PHENYL-DIBENZAZEPINE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION, DIARRHEA AND SCOUR | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1999-06-03 | — | — | WO | disclosed |