Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071507 | 0.87 | AR (0.54) | MRGPRX4LMNAKDM4ECYP3A4AR | |
| SCHEMBL5263668 | 0.81 | ACHE (0.54) | LMNAKDM4ECYP3A4ARACHE | |
| SCHEMBL5630201 | 0.81 | CYP3A4 (0.47) | LMNAKDM4ECYP3A4ARACHE | |
| SCHEMBL28397412 | 0.80 | LMNA (0.43) | LMNAKDM4ECYP3A4ARACHE | |
| SCHEMBL21728056 | 0.80 | LMNA (0.43) | LMNAKDM4ECYP3A4ARACHE | |
| SCHEMBL473532 | 0.78 | LMNA (0.52) | LMNAKDM4ECYP3A4ACHEPOLB | |
| SCHEMBL27935121 | 0.78 | KDM4E (0.56) | LMNAKDM4ECYP3A4ARACHE | |
| SCHEMBL21719017 | 0.78 | CYP3A4 (0.44) | LMNAKDM4ECYP3A4ARACHE | |
| SCHEMBL10662281 | 0.77 | MEN1 (0.45) | MRGPRX4KDM4EVCAM1ARPOLB | |
| SCHEMBL2733341 | 0.77 | LMNA (0.43) | LMNAKDM4ECYP3A4ARACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103687860-B | As P2X7Heterocyclic amide derivatives of receptor antagonists | 埃科特莱茵药品有限公司 | 2016-06-08 | — | — | CN | disclosed |