Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.43 |
| ▸ | RYR2 | Q92736 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807160 | 0.89 | RYR2 (0.44) | RIPK1GPR142RYR2KMT2AKDM4E | |
| SCHEMBL807044 | 0.81 | RYR2 (0.58) | RIPK1GPR142RYR2 | |
| SCHEMBL806996 | 0.71 | RYR2 (0.60) | RIPK1GPR142RYR2 | |
| SCHEMBL10070995 | 0.70 | RIPK1 (0.48) | RIPK1GPR142RYR2 | |
| SCHEMBL2812377 | 0.70 | ABHD6 (0.55) | KMT2AKDM4EHSD17B10ALOX15NPC1 | |
| SCHEMBL3808847 | 0.68 | GPR142 (0.51) | RIPK1GPR142 | |
| SCHEMBL2873071 | 0.67 | MAPK1 (0.65) | KMT2AKDM4EHSD17B10ALOX15NPC1 | |
| SCHEMBL22782412 | 0.67 | HRH3 (0.68) | KMT2AKDM4EHSD17B10ALOX15NPC1 | |
| SCHEMBL16284216 | 0.67 | ABHD6 (0.55) | KMT2AKDM4EHSD17B10ALOX15NPC1 | |
| SCHEMBL10069970 | 0.66 | AKR1C3 (0.55) | RIPK1GPR142RYR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037105-A1 | METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012019076-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2012019071-A1 | METHODS OF PREVENTING AND TREATING SARCOPENIA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |