Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560739 | 0.76 | P2RX7 (0.55) | MEN1KMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL7864022 | 0.72 | P2RX7 (0.46) | KDM4EMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL7568584 | 0.71 | P2RX7 (0.62) | MEN1KMT2AALDH1A1HSD17B10P2RX7 | |
| SCHEMBL28045274 | 0.68 | CYP2D6 (0.38) | MEN1KMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL8081000 | 0.67 | CA1 (0.55) | MEN1KMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL7592357 | 0.66 | HPGD (0.54) | HPGDALDH1A1CYP1A2POLBSMN1; SMN2 | |
| SCHEMBL7518675 | 0.66 | ESRRB (0.49) | TDP1HPGDPOLBP2RX7 | |
| SCHEMBL7658512 | 0.66 | P2RX7 (0.54) | MEN1KMT2AHPGDALDH1A1CYP1A2 | |
| SCHEMBL2809942 | 0.65 | KDM4E (1.00) | KDM4EMEN1KMT2ATDP1HPGD | |
| SCHEMBL7555910 | 0.65 | POLB (0.43) | KDM4EMEN1KMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029661-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |