Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920341 | 0.86 | SMN1; SMN2 (0.60) | MMP8TSHRPIN1GAAMEN1 | |
| SCHEMBL502194 | 0.84 | SMN1; SMN2 (0.61) | MMP8TSHRPIN1GAAMEN1 | |
| SCHEMBL7270510 | 0.81 | KMT2A (0.60) | TSHRMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL2310025 | 0.81 | LMNA (0.62) | MMP8TSHRPIN1MEN1KMT2A | |
| SCHEMBL9021701 | 0.81 | ALDH1A1 (0.50) | KMT2ASMN1; SMN2LMNACYP1A2TDP1 | |
| SCHEMBL28674585 | 0.79 | MMP8 (0.72) | MMP8TSHRPIN1GAAMEN1 | |
| SCHEMBL11092251 | 0.78 | CYP1A2 (0.37) | TSHRGAAKMT2ASMN1; SMN2CYP2D6 | |
| SCHEMBL6596397 | 0.78 | CYP1A2 (0.50) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL28929530 | 0.78 | MMP8 (0.56) | MMP8TSHRPIN1GAAMEN1 | |
| SCHEMBL28929528 | 0.78 | MMP8 (0.56) | MMP8TSHRPIN1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563128-B1 | NEW 3,4-DIHYDROISOQUINOLINE DERIVATES AND NEW PHARMACEUTICAL USE OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNULATED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-03-24 | — | — | EP | claimed |
| US-5686462-A | FUSED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1997-11-11 | — | — | US | claimed |
| US-5665729-A | CARBOCYCLIC OR HETEROCYCLIC FUSED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1997-09-09 | — | — | US | claimed |
| EP-0781556-A1 | Use of condensed dihydropyridines for the treatement of chronic inflammatory processes | BOEHRINGER INGELHEIM KG (DE) | 1997-07-02 | — | — | EP | claimed |
| EP-0563128-A1 | NEW 3,4-DIHYDROISOQUINOLINE DERIVATES AND NEW PHARMACEUTICAL USE OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNULATED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1993-10-06 | — | — | EP | claimed |
| EP-0251194-B1 | USE OF CARBOCYCLIC AND HETEROCYCLIC CONDENSED DIHYDROPYRIDINES FOR THE PREPARATION OF CARDIOPROTECTIVE REMEDIES AND HETEROCYCLIC AND CARBOCYCLIC CONDENSED DIHYDROPYRIDINES AND METHODS AND INTERMEDIATES FOR THEIR PREPARATION | BOEHRINGER INGELHEIM KG (DE) | 1993-03-31 | — | — | EP | claimed |
| WO-1992011010-A1 | NEW 3,4-DIHYDROISOQUINOLINE DERIVATES AND NEW PHARMACEUTICAL USE OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNULATED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1992-07-09 | — | — | WO | claimed |
| EP-0251194-A1 | Use of carbocyclic and heterocyclic condensed dihydropyridines for the preparation of cardioprotective remedies and heterocyclic and carbocyclic condensed dihydropyridines and methods and intermediates for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1988-01-07 | — | — | EP | claimed |
| US-6034094-A | BRAIN DISORDERS; ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2000-03-07 | — | — | US | disclosed |
| EP-0563128-B1 | NEW 3,4-DIHYDROISOQUINOLINE DERIVATES AND NEW PHARMACEUTICAL USE OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNULATED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5686462-A | FUSED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1997-11-11 | — | — | US | disclosed |
| US-5665729-A | CARBOCYCLIC OR HETEROCYCLIC FUSED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1997-09-09 | — | — | US | disclosed |
| EP-0781556-A1 | Use of condensed dihydropyridines for the treatement of chronic inflammatory processes | BOEHRINGER INGELHEIM KG (DE) | 1997-07-02 | — | — | EP | disclosed |
| EP-0781556-A1 | Use of condensed dihydropyridines for the treatement of chronic inflammatory processes | BOEHRINGER INGELHEIM KG (DE) | 1997-07-02 | — | — | EP | disclosed |
| EP-0251194-A1 | Use of carbocyclic and heterocyclic condensed dihydropyridines for the preparation of cardioprotective remedies and heterocyclic and carbocyclic condensed dihydropyridines and methods and intermediates for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1988-01-07 | — | — | EP | disclosed |
| US-4558123-A | CHEMICAL INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1985-12-10 | — | — | US | disclosed |
| US-4515719-A | Azetidinone sulfinic acids from cephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1985-05-07 | — | — | US | disclosed |
| EP-0132395-A1 | Improvements in or relating to the preparation of azetidinone sulfinic acids from cephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1985-01-30 | — | — | EP | disclosed |
| EP-0132394-A1 | Improvements in or relating to the preparation of 3-exomethylene cephalosporins | ELI LILLY AND COMPANY (US) | 1985-01-30 | — | — | EP | disclosed |
| US-4175185-A | ESTERIFICATION, IMINOHALOGENATION, ETHERIFICATION, HYDROLYSIS, DEESTERIFICATION | MEIJI SEIKA KAISHA LTD. (JP) | 1979-11-20 | — | — | US | disclosed |