Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | HSD17B7 | P56937 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.35 |
| ▸ | LIPA | P38571 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239824 | 0.93 | G6PD (0.37) | G6PDSRD5A1 | |
| SCHEMBL8724887 | 0.86 | G6PD (0.32) | G6PD | |
| SCHEMBL8071938 | 0.84 | SRD5A2 (0.37) | SRD5A1 | |
| SCHEMBL8063891 | 0.84 | SRD5A2 (0.36) | — | |
| SCHEMBL9113667 | 0.81 | SRD5A1 (0.42) | SRD5A1 | |
| SCHEMBL8525513 | 0.81 | LMNA (0.36) | — | |
| SCHEMBL9572349 | 0.80 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL8078855 | 0.78 | HSD17B7 (0.59) | HSD17B7SRD5A1 | |
| SCHEMBL8064026 | 0.78 | HSD17B7 (0.59) | HSD17B7SRD5A1 | |
| SCHEMBL8071947 | 0.78 | HSD17B7 (0.59) | HSD17B7SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641208-B1 | 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO INC (US) | 2000-08-02 | — | — | EP | claimed |
| EP-0641208-A4 | 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS. | MERCK & CO INC (US) | 1995-08-30 | — | — | EP | claimed |
| EP-0641208-A1 | 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1995-03-08 | — | — | EP | claimed |
| US-5710275-A | ENZYME AND HORMONE INHIBITORS | MERCK & CO., INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0641208-A4 | 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS. | MERCK & CO INC (US) | 1995-08-30 | — | — | EP | disclosed |
| EP-0641208-A1 | 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | disclosed |