Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806789 | 0.88 | PIK3CD (0.50) | IRAK4KITKCNH2JAK2PIK3CD | |
| SCHEMBL790084 | 0.80 | JAK2 (0.48) | KCNH2JAK2ATRPIK3CAHPGD | |
| SCHEMBL806763 | 0.79 | KIT (0.49) | IRAK4KITKCNH2PIK3CDPIK3R1 | |
| SCHEMBL807212 | 0.76 | PIK3CD (0.46) | KITKCNH2JAK2PIK3CDPIK3R1 | |
| SCHEMBL807280 | 0.75 | PIK3CD (0.50) | KCNH2PIK3CDPIK3R1PIK3CAMTOR | |
| SCHEMBL791064 | 0.71 | PIK3CG (0.81) | PIK3CDPIK3R1PIK3CAMTORPIK3CG | |
| SCHEMBL10289033 | 0.71 | PI4KA (0.74) | PIK3CDPIK3R1PIK3CAMTORPIK3CG | |
| SCHEMBL807059 | 0.70 | PIK3C3 (0.46) | PIK3CGHPGDPI4KA | |
| SCHEMBL12928953 | 0.70 | PIK3CA (0.59) | KITPIK3CDPIK3R1PIK3CAMTOR | |
| SCHEMBL10274836 | 0.69 | KCNH2 (0.48) | KCNH2PIK3CDMETPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |